The TRAIN-HEART consortium, funded by the European Commission (2019-2023), is made up to train a league of 15 promising fellows that harness novel insights in the pathogenesis of ischemic heart failure, study the therapeutic potential of existing RNA therapeutics and improve its efficacy by the design of novel drug delivery systems.


TRAIN-HEART brings together leading academic teams and (biotech) companies covering various disciplines ranging from fundamental research to clinical pharmacology and gene therapy to drug delivery applications, have teamed up in the European Union.

Research Programme

The TRAIN-HEART network aims to gain viable insight in the pathogenesis of ischemic heart failure which will serve as a basis for drug discovery and drug delivery efforts that aim to therapeutically target specific molecules and mechanisms within cardiomyocytes for the treatment of ischemic heart failure.  


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Chitosan hydrogels incorporating colloids for sustained drug delivery

The research group at Lyon Unversity recently published a review to report on the many existing complex systems composed of chitosan hydrogels embedding different types of colloids used as drug delivery devices to delay the release of drugs. The various biomedical applications of such final systems are also detailed in this review.


Dr. Marc Hirt presented his work at the Frontiers in Cardiovascular Biomedicine congress 2022

Lead scientist Dr. Marc Hirt of University Medical Center Hamburg-Eppendorf and supervisor of Kinga Wrona (TRAIN-HEART fellow) presented his work at the Frontiers in Cardiovascular Biomedicine congress 2022


Role of the epigenome in heart failure

The group of Prof. Condorelli (Humanitas Hospital Milan, Italy) recently published a review on the impact of environmental factors, such as diet, smoking, and lifestyle, as pathogenic factors in heart failure development. Epigenetic changes can arise as a consequence of these factors.


The Porto meeting of the TRAIN-HEART network was a major success

From 16-18 February the first hybrid TRAIN-HEART network meeting was organised by our partner: University of Porto.


A spray to protect against lung damage from Covid-19 developed by the TRAIN-HEART group at TUM (Munich)

The research team led by Stefan Engelhardt, Professor of Pharmacology and Toxicology at the Technical University of Munich (TUM) and Principal Investigator in the TRAIN-HEART network, has developed a new RNA drug that can prevent inflammatory lung damage. The German Federal Ministry of Education and Research (BMBF) is supporting further development of the drug as part of the TUM spin-off "rnatics" with around 7 million euros.