The TRAIN-HEART consortium, funded by the European Commission (2019-2023), is made up to train a league of 15 promising fellows that harness novel insights in the pathogenesis of ischemic heart failure, study the therapeutic potential of existing RNA therapeutics and improve its efficacy by the design of novel drug delivery systems.


TRAIN-HEART brings together leading academic teams and (biotech) companies covering various disciplines ranging from fundamental research to clinical pharmacology and gene therapy to drug delivery applications, have teamed up in the European Union.

Research Programme

The TRAIN-HEART network aims to gain viable insight in the pathogenesis of ischemic heart failure which will serve as a basis for drug discovery and drug delivery efforts that aim to therapeutically target specific molecules and mechanisms within cardiomyocytes for the treatment of ischemic heart failure.  


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Checkout the new and impressive paper "Nano-miR-133a Replacement Therapy Blunts Pressure Overload–Induced Heart Failure"

Great work conducted by the groups at Humanitas Mirasole (Milan, Italy) and led by Dr. Daniele Catalucci.


The long non-coding RNA NRON promotes the development of cardiac hypertrophyin the murine heart

Two TRAIN-HEART groups teamed up (Hannover Medical School & Technical University Munich) to elucdiate the promoting role of long non-coding RNA NRON in the development of cardiac hypertrophy in the murine heart.


Presentation of Hussein at the 7th Int. Congress of the European Polysaccharide Network of Excellence (EPNOE)

Hussein Genedy, TRAIN-HEART fellow at Universite Claude Bernard Lyon 1, presented his work at the 7th International Congress of the European Polysaccharide Network of Excellence (EPNOE Association)


Outstanding webinar on Biocompatible Drug Delivery Systems organized by Université Claude Bernard Lyon 1

In the beginning of July, the Université Claude Bernard Lyon 1, beneficiary in the TRAIN-HEART network, organized a full-day webinar on Biocompatible Drug Delivery Systems in which all TRAIN-HEART fellows attended.


The fifth TRAIN-HEART Network Meeting!

The fifth TRAIN-HEART Network Meeting, gathering all partners and research fellows, took place from the 23rd and 24th of June 2021.