TRAIN-HEART Network

The TRAIN-HEART consortium, funded by the European Commission (2019-2023), is made up to train a league of 15 promising fellows that harness novel insights in the pathogenesis of ischemic heart failure, study the therapeutic potential of existing RNA therapeutics and improve its efficacy by the design of novel drug delivery systems.


People

TRAIN-HEART brings together leading academic teams and (biotech) companies covering various disciplines ranging from fundamental research to clinical pharmacology and gene therapy to drug delivery applications, have teamed up in the European Union.


Research Programme

The TRAIN-HEART network aims to gain viable insight in the pathogenesis of ischemic heart failure which will serve as a basis for drug discovery and drug delivery efforts that aim to therapeutically target specific molecules and mechanisms within cardiomyocytes for the treatment of ischemic heart failure.  


Contact

If you have any questions you can fill in the form or mail us directly: info@train-heart.eu.





News

Testimonial of TRAIN-HEART fellow Deepak Balamurali as presenter at the annual Congress of the European Heart Rhythm Association (EHRA)

Deepak Balamurali, TRAIN-HEART fellow appointed at Maastricht University was awarded a congress grant covering the costs of registration for the EHRA Congress 2021(virtual) and EHRA Congress 2022 (tentatively in-person). He drafted a testimonial on this unique experience.

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Tremendous paper published on a potential mechanism for COVID-19 disease pathogenesis by the group of Prof. Mauro Giacca (King's College)

An exciting paper, resuling from a huge amount of excellent work by the group of Prof. Mauro Giacca at King's College London has been published in Nature last month!

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JMCC-ISHR Cardiovascular Webinar - Cardiac Epigenetics Special Issue 12 July 2021

Join the ISHR webinar on the Journal of Molecular and Cellular Cardiology's Special Issue on Cardiac Epigenetics: Driving signals to the cardiac epigenome in development and disease. Guest Editors Emma Louise Robinson, Manuel Rosa-Garrido, Chukwuemeka George Anene-Nzelu will host the discussion with two authors from the special issue: Ralf Gilsbach and Justus Stenzig.

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Great paper on a new microRNA program that stimulates cardiac regeneration from collaborative work between King's College and Maastricht University.

Myocardial regeneration is restricted to early postnatal life, when mammalian cardiomyocytes still retain the ability to proliferate. The molecular cues that induce cell cycle arrest of neonatal cardiomyocytes towards terminally differentiated adult heart muscle cells remain obscure. In this 2021 paper it is reported that the miR-106b∼25 cluster is higher expressed in the early postnatal myocardium and decreases in expression towards adulthood, especially under conditions of overload, and orchestrates the transition of cardiomyocyte hyperplasia towards cell cycle arrest and hypertrophy by virtue of its targetome.

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HFA Winter Meeting 2021 Abstract published in European Journal of Heart Failure

All abstracts of previous Heart Failure Association Winter Research Meeting (January 2021) are now published in the European Journal of Heart Failure: https://doi.org/10.1002/ejhf.2100

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