ESR Project 10

This PhD student will test new non coding RNA therapeutics in engineered heart tissue derived from human induced pluripotent stem cells as a highly translational platform. Effects on pathologic remodelling processes will be studied by inducing aspects of heart failure in the engineered heart tissue, with typical phenotypic alterations such as reduced contractile force, increased fibrosis and impaired diastolic relaxation as observed in patients with heart failure.


- Technical University Munich (group of Prof. Engelhardt, Institute for Pharmacology and Toxicology)

- Mirabilis Therapeutics BV (Dr Wit, pharmaceutical development)

Host Institution

University Medical Center Hamburg/Eppendorf


Main supervisor: Prof. Thomas Eschenhagen

Co-supervisor: Dr Marc Hirt