ESR Project 15

This PhD student will use an optimised dose and route of administration to treat pigs subjected to myocardial infarction with intracardiac delivery of nanoformulated sense oligonucleotides (mimics). The therapeutic benefit will be measured by serial MRI/ invasive haemodynamic evaluations, followed by clinical chemistry, immunohistochemical data, liver and kidney sections of the porcine model to test for absence of toxicological side effects.


Collaborators:

- Technical University Munich (group of Prof Engelhardt, Institute for Pharmacology and Toxicology)

- Accelero Bioanalytics GmbH (Dr Lange, business development)

Host Institution

University of Porto


Supervisors:

Main supervisor: Prof. Adelino Leite Moreira

Co-supervisor: Dr André Lourenço