POSITION GRANTED

ESR Project 4

This PhD student will use SNPs from pre-existing large-scale GWAS of patients with myocardial infarction or coronary artery disease and epigenetic datasets of ischemic heart failure to map genomic regions that associate with changes in 3 selected non coding RNA candidates and their targetomes. The student will generate uniform annotation of data gathered from different genomic and genetic platforms. Data integration of epigenetically open genomic regions and the presence of SNPs in genomic regions that are predicted to influence non coding RNA gene expression or function with differentially expressed non coding RNAs allows the construction of a philogenetically conserved non coding RNA/targetome dataset of ischemic heart failure. The main result of this project will be the construction of a philogenetically conserved targetome dataset of ischemic heart failure.


Collaborators:

- Humanitas Mirasole (group of Prof. Condorelli, cardiovascular medicine)

- Miltenyi Biotec GmbH (group of Dr Eckardt, cardiac research)


Host Institution

Maastricht University


Supervisors:

Main supervisor: Prof. Monika Stoll

Co-supervisor: Dr Aaron Isaacs