POSITION GRANTED

ESR Project 3

This PhD student willuse overexpression and silencing libraries in unbiased robotic-based screenings at a 384-well level coupled to automated segmentation microscopy, allowing high-content analysis of 3 candidate non coding RNA sense and antisense molecules as well as small interfering RNAs for the interactomes with regard to their phenotypic readouts on major cell types of the myocardium. The main result of this project will be the functional characterization of non coding RNA candidates as therapeutic targets in ischemic heart failure.


Collaborators:

- University Medical Center Hamburg-Eppendorf (group of Prof. Eschenhagen, experimental pharmacology and toxicology)

- Miltenyi Biotec GmbH (group of Dr Eckardt, cardiac research)

Host Institution

King's College London


Supervisors:

Main supervisor: Prof. Mauro Giacca

Co-supervisor: Dr Elena Chiavacci